After the GLP-1
What happens when you stop.
The most-asked question in obesity medicine. We answer it honestly, up front, because we'd rather you know now than after you've paid.
Most people return some weight
Roughly two-thirds of lost weight returns within 12 months of discontinuing semaglutide in published extension data. This is the body's setpoint reasserting itself, not a moral failure.
STEP-1 Extension
Maintenance dosing is real
Obesity medicine is researching maintenance protocols: lower weekly dose, every-other-week, seasonal cycling. Your provider can prescribe a maintenance plan at goal weight.
ASBP 2024
Lifestyle reinforcement holds
Patients who pair the compound with structural behavior change — protein-prioritized eating, resistance training, sleep — retain more loss after taper.
SURMOUNT-3 lifestyle arm